Emilin1 Links TGF-β Maturation to Blood Pressure Homeostasis
نویسندگان
چکیده
Luca Zacchigna, Carmine Vecchione, Antonella Notte, Michelangelo Cordenonsi, Sirio Dupont, Silvia Maretto, Giuseppe Cifelli, Alessandra Ferrari, Angelo Maffei, Carla Fabbro, Paola Braghetta, Gennaro Marino, Giulio Selvetella, Alessandra Aretini, Claudio Colonnese, Umberto Bettarini, Giovanni Russo, Sandra Soligo, Maddalena Adorno, Paolo Bonaldo, Dino Volpin, Stefano Piccolo,* Giuseppe Lembo,* and Giorgio M. Bressan* Developmental Signaling Laboratory, Department of Histology Microbiology and Medical Biotechnologies, University of Padua, viale Colombo 3, 35121 Padua, Italy Department of Angiocardioneurology, I.R.C.C.S. Neuromed Institute, Loc. Camerelle, 86077 Pozzilli (IS), Italy Department of Experimental Medicine and Pathology, La Sapienza University, V.le Regina Elena 324, 00161 Rome, Italy Mouse Genetics Laboratory, Department of Histology Microbiology and Medical Biotechnologies, University of Padua, viale Colombo 3, 35121 Padua, Italy These authors contributed equally to this work. *Contact: [email protected] (S.P.); [email protected] (G.L.); [email protected] (G.M.B.) DOI 10.1016/j.cell.2005.12.035
منابع مشابه
Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure.
OBJECTIVE Emilin-1 is a protein of elastic extracellular matrix involved in blood pressure (BP) control by negatively affecting transforming growth factor (TGF)-β processing. Emilin1 null mice are hypertensive. This study investigates how Emilin-1 deals with vascular mechanisms regulating BP. METHODS AND RESULTS This study uses a phenotype rescue approach in which Emilin-1 is expressed in eit...
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عنوان ژورنال:
- Cell
دوره 124 شماره
صفحات -
تاریخ انتشار 2006